Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain?

welcome to another MedCram Covid nineteen update total confirmed cases ninety six thousand total deaths 3300 total recovered fifty three.

welcome to another MedCram Covid
nineteen update total confirmed cases ninety six thousand total deaths 3300
total recovered fifty three thousands going over to the world ometer site
total cases were leveling off now starting to pick up we are definitely in
the epidemic face here outside of china i like to go to the world ometer for the
latest updates which is on the home page and you can see here for March 5th and
of course the day is not done just beginning two new cases here in the
United States four new cases in Thailand a hundred and forty five new cases in
South Korea they are testing aggressively in South Korea as you can
see and if you look at the completed day four yesterday you will see two new
deaths in the United States and 34 new cases here as well the West Coast is the
place where the epidemic is occurring most we have twelve new cases in
Washington State and twelve new cases in California five hundred and eighty seven
new cases in just one day in Italy with twenty eight new deaths if we look at
the worldwide closed cases we can see that the death rate is still falling as
the virus progresses death rate falling under six percent we know that the w-h-o
yesterday declared that the world’s wide estimated case fatality rate is
somewhere at the three percent range they had previously said around two
percents looking at active cases that are going on right now there about
38,000 of those 32,000 are in mild condition probably don’t even need to be
in the hospital seventeen percent are in serious or critical condition these are
people in the hospital or even in the intensive care unit so this is a list
that the EPA is put together of registered antimicrobial products for
use against coronavirus SARS cub – the cause of kovin 19 this is what we’ve
been waiting for it was put out on March 3rd we’ll put the link to this in the
description below so you can see that bleach and peroxide and certain
chemicals here are to you by the way is ready to use and dilute a bowl something
that you can dilute but you can see here there’s a number of products that
are certified to clean and disinfect surfaces that are colonized by the SARS
cub to virus so I want to talk about this interesting research article the
research was done by experts at Peking University in Beijing Shanghai
University and the Chinese Academy of Sciences the gist of the article is we
have the SARS cuff – virus and what they’re saying is that there’s two types
there is an ancestral s type which was starting before at the very beginning of
the outbreak and there’s been a mutation that’s branched off the original is
known as the S form and the mutated form is known as the L form how they differ
is at a single point where there’s been a mutation of one nucleotide that’s
known as an SNP a single nucleotide polymorphism so for instance in the
genome instead of having an a G T which would be in the S type the mutated L
version the one that’s branched off is gonna be a G C at that point there’s
been a change of a nucleotide and that’s caused a difference this L and s form
the S being less severe but the more original form was seen only 30% of the
time in wuhan the more severe one ended people up in the hospital and they were
quarantine that’s been reduced and it’s been decreasing whereas the 30% one is
the one that seems to be spreading and so let’s take a look at some of their
data in that article and here is the article itself we’ll put a link in the
description below and here’s a Fulani tree where you can see that the red
arrow is the S and the blue arrow the L there’s also further analysis again the
red dots being the S version and the blue dots being the descendants or the
more severe one here you can see the – L and s types and you can see that there
is a transition there where the S type seems to be more similar to the other
coronaviruses with a T at this position in this gene changed to a C and that
became more variant in the L type which is the blue one and you can also see it
where this went for instance you can see here there’s a strain that went to
France Germany there’s some that have gone to
South Korea the United States the United States Singapore Japan but also some of
the s-type has also gone to the United States to Australia to Korea Japan etc
etc in terms of the number of strains looking at this first part of the graph
outside of Wuhan there was a lot more of the s-type whereas inside Wuhan there
was a much much higher concentration of the newer l-type which was also more
severe looking at the second part of the graph before January 7 versus after
January 7 the s-type was making much more of a comeback unfortunately you
can’t really choose what form of the virus you get infected with and
according to the authors of the study you may actually get both apparently the
virus is identified from a patient in Australia had multiple degenerated
nucleotides and the best explanation is that this patient was infected by at
least two different strains of SARS curve two viruses and you can see here
that looking at the two nucleotides at these positions they were different even
though this was in the same person of course the other possibility is that the
patient may have had mutated viruses in them at the same time which is unlikely
the authors and their abstract saying that these findings strongly support an
urgent need for further immediate comprehensive studies that combine
genomic data epidemiological data and chart records of the clinical symptoms
of patients with coronavirus disease 2019 thanks for joining us

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